William K. Bowes, Jr. died peacefully at home on December 28, 2016 after a long illness. A leading member of the first generation of venture capitalists, he was a private investor in many of the earliest startups in what became known as Silicon Valley. In 1981, he founded U.S. Venture Partners where his conviction that venture capitalists should actively guide companies rather than simply invest in them was a basic principle. His focus was the biomedical industry, an interest he inherited from his physician father. The investment of which he was most proud was in Amgen, a pioneering biotechnology company of which he was founding shareholder and the startup’s first chairman and treasurer. Not a man of many words, he was known for his brief, to-the- point interjections in business negotiations. In later years, Bowes’s interest turned to philanthropy in the fields of science, the arts, education, and the environment. Among his many generous bequests was a recent pledge of $50 million to the University of California, San Francisco to support young investigators. A far cry from the hard-driving venture capitalist, Bowes was known for his self-effacing manner and personal warmth. For details of his life and contributions, read his oral history transcript.